Tadapox is a combination of two active ingredients Tadalafil and Dapoxetine which cures ED and PE respectively. Tadalafil helps in combating ED by its action of inhibiting the action of PDE-5 enzyme which results in the elevation of the levels of NO and guanylyl cyclase. Furthermore, this leads to the increase in the concentration of cGMP which is the potent vasodilator and dilates the blood vessels of the penis so that more influx of the blood in the penis causes it to be firm and hard. This is how ED is resolved. Dapoxetine on the other hand works on the central neurons and at the neuroreceptor level and inhibits the reuptake of a biochemical in the brain called serotonin which acts as anti-depressant leading to delay in semen ejaculation.