Actilis 20mg-Long Lasting Solid Erection

Mechanism of Action

Inhibition of PDE5 Enzyme

Phosphodiesterase type 5 (PDE5) is an enzyme found in the smooth muscle cells of the penis. PDE5 breaks down cyclic guanosine monophosphate (cGMP), a molecule that promotes relaxation of blood vessels. By inhibiting PDE5, Tadalafil prevents the breakdown of cGMP, allowing it to accumulate in the penile tissues.

Relaxation of Blood Vessels

Increased cGMP levels relax the smooth muscles in the walls of blood vessels in the penis. This results in vasodilation, or the widening of blood vessels, which enhances blood flow.

Improved Erection

During sexual stimulation, the enhanced blood flow helps achieve and sustain an erection suitable for sexual activity. Without sexual stimulation, the medication will not cause an erection, ensuring it works in harmony with natural arousal.

Duration of Action: Actilis 20 mg provides an extended window of effectiveness, lasting up to 36 hours, allowing for more spontaneity in sexual activity.

Treatment of BPH: Actilis 20mg can also relax muscles in the prostate and bladder, alleviating symptoms of benign prostatic hyperplasia (BPH), such as difficulty urinating.

Long Half-Life: about 17.5 hours, which contributes to its prolonged duration of action compared to shorter-acting medications like sildenafil.

Consistent Results: The formulation of Actilis ensures reliable absorption and predictable effects.

Onset: Begins working within 30-60 minutes after ingestion. Sexual stimulation is required for it to be effective.

Duration: Effects last for up to 36 hours, allowing flexibility and spontaneity in planning sexual activity.

How It Supports Erectile Function

Actilis does not directly cause an erection. It enhances the natural process involved in achieving one during sexual stimulation. It addresses the most prevalent root cause of ED, which is insufficient blood flow to the penis.

1. Actilis 2.5 mg

Actilis 2.5mg is a low-dose option taken daily. It is for men who want a steady, daily level of Tadalafil for spontaneous sexual activity and those with mild ED or seeking management of both ED and symptoms of benign prostatic hyperplasia (BPH). Take one daily at the same time each day.

2. Actilis 5 mg

Actilis 5mg is for a moderate daily dose for men who need slightly higher daily support for ED or BPH symptoms, suitable for individuals who respond well to daily low-dose therapy. Take one daily at the same time each day.

3. Actilis 10 mg

Actilis 10mg is a starting dose, as-needed for men with moderate ED who do not require the maximum dose and those trying Tadalafil for the first time. Take it as needed, at least 30-60 minutes before sexual activity. It is not for daily consumption.

4. Actilis 20 mg

Actilis 20mg is the maximum-strength dose, as needed for men with moderate to severe ED who require the highest dose for optimal results and those who have not achieved desired results with lower doses. Take it as needed, at least 30-60 minutes before sexual activity. One should not take it more than once every 24 hours.

How do you choose the Right Dose?

Daily Use (2.5 mg or 5 mg)

Actilis 2.5mg or 5mg is ideal for men who expect frequent sexual activity (e.g., more than twice a week) and prefer a consistent, low-level effect. It provides continuous support with no planning for sexual activity.

As-Needed Use (10 mg or 20 mg)

Actilis 10mg or 20mg  is suitable for men who engage in sexual activity less frequently, those who prefer to take the medication only when required, and need a potent single dose for each occasion.

Factors to Determine the Dose

The severity of the ED

Men with severe ED may need the 20 mg dose, while those with mild symptoms may benefit from lower doses.

Health Conditions

Liver or kidney impairments may require lower doses.

Age

Older individuals may start with lower doses to minimize potential side effects.

Previous Experience

Doctors may prescribe Actilis 10 mg for First-time users to assess tolerance and effectiveness.

Timing

Take the as-needed doses 30-60 minutes before sexual activity. Take the daily doses at the same time every day, regardless of sexual activity. You can take it with or without meals. However, a high-fat meal may delay the onset of action. Do not take more than one dose per 24 hours, regardless of strength.

Steps for Taking Actilis 20 mg

Follow Prescribed Instructions. Take Actilis as your doctor has directed. Do not exceed the recommended dose. Take one tablet of Actilis at least 30-60 minutes before planned sexual activity. For daily lower doses, take at the same time each day, regardless of sexual activity. Swallow the tablet whole with a glass of water. Do not crush, chew, or split the tablet unless specifically instructed by your doctor. You can take Actilis on an empty stomach or with meals. Avoid high-fat meals close to taking the medication, as they may delay its effects.

1. Medical History and Health Conditions

Heart Problems

Avoid if you have severe heart conditions like unstable angina, recent heart attack, or stroke. Use it cautiously if you have a history of cardiovascular disease or an irregular heartbeat.

Liver or Kidney Disease

Reduced doses may be necessary, as these conditions affect how your body processes Tadalafil.

Blood Pressure Issues

It is not for individuals with very low or uncontrolled high blood pressure.

Eye Disorders

Avoid if you have a history of non-arteritic anterior ischemic optic neuropathy (NAION) or hereditary eye conditions like retinitis pigmentosa.

Peyronie’s Disease

Use it cautiously if you have a penile deformity or scarring, as there is an increased risk of complications.

2. Drug Interactions

Nitrates

Never take Actilis with nitrate medications (e.g., nitroglycerin) for chest pain, as this can cause a dangerous drop in blood pressure.

Alpha-Blockers

Use cautiously with medications for high blood pressure or prostate problems, as this combination can also lead to low blood pressure.

Other ED Medications

Do not combine with other PDE5 inhibitors like sildenafil (Viagra) or vardenafil (Levitra).

CYP3A4 Inhibitors

Medications like ketoconazole, itraconazole, or ritonavir may increase Tadalafil levels in the blood, raising the risk of side effects.

Alcohol

Excessive alcohol consumption can increase the risk of side effects like dizziness, headache, or fainting.

Grapefruit & juice

Avoid grapefruit or grapefruit juice, as they can interfere with the metabolism of Tadalafil, increasing the likelihood of side effects.

Dietary Fat

Avoiding it with high-fat meals may delay the onset of its effects.

Hydration

Drink plenty of water to minimize the risk of dehydration-related side effects, such as headaches.

Elderly Individuals

Start with a lower dose, as older adults may process Tadalafil more slowly, increasing the risk of side effects.

Pregnancy and Breastfeeding

It is not for women. You must avoid it during pregnancy or breastfeeding.

Children and Adolescents

Not suitable for individuals under 18 years of age.

• Headache-The most common side effect
• Flushing-Warmth or redness, especially on the face, neck, or chest.
• Nasal Congestion-Stuffy or runny nose.
• Indigestion (Dyspepsia)-Stomach discomfort or acid reflux.
• Back/Muscle Pain-General soreness or muscle aches.
• Dizziness-Feeling lightheaded or faint.
• Nausea-Queasiness or upset stomach.
• Vision Changes- blurred vision, increased sensitivity to light, or a slight blue tint to vision.
• Fatigue-Feeling tired or lethargic.

• Priapism - An erection lasting over four hours, often painful
• Sudden Vision Loss - in one or both eyes
• Sudden Hearing Loss - Rapid loss of hearing, often accompanied by tinnitus (ears ringing) or dizziness.
• Chest Pain or Irregular Heartbeat - pain, tightness, or pressure in the chest. Irregular heartbeat or palpitations.
• Severe Allergic Reaction (Anaphylaxis) - Swelling of the face, lips, tongue, or throat. Difficulty breathing or swallowing. Severe rash, itching, or hives.
• Severe Drop in Blood Pressure - Extreme dizziness or fainting. Blurred vision or confusion.

What makes Actilis 20 mg stand out?

It provides robust results for men who have not responded well to lower doses. For cost-conscious users who want it in bulk, it is an affordable alternative to branded Tadalafil medications. It is ideal for individuals seeking a medication with an extended duration of action.

What Actilis 20mg Does Not Do?

Actilis does not increase sexual desire (libido). It does not prevent sexually transmitted infections (STIs) or act as a contraceptive. It manages the symptoms of ED but does not address underlying psychological or hormonal issues.

What do I avoid to get the best effects?

Limit alcohol consumption as it can reduce the effectiveness of Actilis and increase the risk of side effects like dizziness or low blood pressure. Drink plenty of water to stay hydrated, which may help minimize headaches or other mild side effects. Grapefruit and its juice can interfere with the metabolism of Tadalafil, increasing the risk of side effects.

How do you minimize side effects?

Take Actilis with water and avoid heavy or fatty meals. Limit alcohol intake to reduce the risk of dizziness or low blood pressure. Stay hydrated to alleviate headaches and fatigue.

How do I store Actilis 20mg?

Store at room temperature (20-25°C or 68-77°F). Keep it dry, away from moisture, heat, and sunlight, children and pets.

When do you seek emergency help?

Seek medical interventions if you experience chest pain, difficulty breathing, vision or hearing loss, prolonged erection (priapism), or severe allergic reactions.