Avana 100 mg works through its active ingredient, Avanafil, a phosphodiesterase type 5 (PDE5) inhibitor, to treat erectile dysfunction (ED). It enhances blood flow to the penis to achieve and maintain an erection during sexual arousal.
Mechanism of Action
Avanafil addresses ED by intervening in the biochemical processes that regulate blood flow to the penis. Sexual arousal triggers the release of nitric oxide (NO) in the penile tissues. Nitric oxide activates Guanylate Cyclase enzymes, which increases cyclic guanosine monophosphate (cGMP) levels.
Role of cGMP
CGMP relaxes the smooth muscles in the walls of blood vessels in the penis. This relaxation allows blood vessels to dilate, increasing blood flow to the erectile tissue and resulting in an erection.
Breakdown by PDE5 Enzyme
Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cGMP, causing blood vessels to constrict, reducing blood flow, and ending the erection.
How Avana 100mg Works?
PDE5 Inhibition
Avanafil selectively inhibits the PDE5 enzyme, preventing the breakdown of cGMP. It leads to sustained levels of cGMP, maintaining blood vessel relaxation and enhancing blood flow to the penis during sexual stimulation. It leads to a firm and lasting erection. Avana 100 mg enhances the body’s natural erectile response but does not cause spontaneous erections. Sexual arousal is essential for nitric oxide release, which activates the cGMP pathway.
Rapid Onset of Action
Quick Absorption
The body absorbs Avanafil rapidly into the bloodstream, with effects starting as early as 15 minutes after ingestion. It makes Avana 100 mg one of the fastest ED medications available, ideal for spontaneous intimacy. Its shorter half-life compared to drugs like Tadalafil ensures it leaves the system faster, reducing the likelihood of lingering side effects. Avanafil is highly selective for PDE5 enzymes found in the penile tissue. This precision minimizes its effect on other PDE enzymes in the body, reducing off-target side effects such as those affecting vision or heart function.
Stepwise Avana 100mg action mechanism
- During Sexual Stimulation, nitric oxide release triggers cGMP production.
- Avanafil gets into the bloodstream and begins inhibiting PDE5 enzymes.
- CGMP levels increase, promoting blood vessel relaxation.
- Sustained cGMP levels allow blood vessels in the penis to dilate, resulting in improved blood flow.
- A firm erection during sexual activity.
- When sexual stimulation ends, cGMP levels naturally decrease, and the erection subsides.