Avanafil 50mg-A New Generation ED Remedy for Quickest Erection

Avanafil Action Mechanism

Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor. It inhibits and slows the effects of PDE 5 enzymes. PDE5 breaks down cGMP in penile tissues, preventing erection. However, it works only when the user feels sexual arousal.

Inhibition of PDE5 Enzyme

Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a molecule essential for relaxing smooth muscles in blood vessels. Avanafil selectively inhibits PDE5, preventing the breakdown of cGMP in the penis.

Relaxation of Blood Vessels

Increased cGMP levels relax the smooth muscles in the walls of the penile blood vessels. This process, known as vasodilation, widens the blood vessels and allows more blood to flow into the corpora cavernosa (spongy tissues in the penis).

Improved Blood Flow

During sexual stimulation, this enhanced blood flow leads to a firm and sustained erection. Without sexual stimulation, cGMP levels remain low, so the medication does not cause an automatic erection.

Rapid Onset

Avanafil is one of the fastest-acting ED medications, starting within 15-30 minutes after ingestion. It makes it ideal for spontaneous use.

Shorter Half-Life

Avanafil clears from the body more quickly than other ED medications like tadalafil, reducing the risk of prolonged side effects.

High Selectivity for PDE5

Avanafil targets PDE5 more specifically than older medications, minimizing its impact on other PDE enzymes in the body. It reduces side effects, such as vision changes or other systemic reactions.

How to Take Avanafil 50 mg?

To use Avanafil 50 mg effectively and safely, follow these instructions:

Sexual stimulation required: Avanafil enhances natural erectile processes but does not cause an automatic erection. Sexual arousal is necessary for the medication to work. 

Timing: Take one tablet approximately 15-30 minutes before sexual activity. The quick onset allows for greater spontaneity compared to some other ED medications.

Swallow with Water: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet because it may alter its absorption and effectiveness.

With or Without Food: Take Avanafil with or without meals.

High-Fat Meals: While it is less affected by food than sildenafil, high-fat meals may slightly delay its onset of action.

Dosage Limit: Do not take more than one dose in 24 hours to avoid the risk of side effects or overdose.

Avanafil Common Doses

1. Avanafil 50 mg

It is the starting dose for new users. It is for men with mild to moderate ED, individuals sensitive to higher doses, or prone to side effects. It provides effective results with a lower risk of side effects.

2. Avanafil 100 mg

It is the standard dose for most users for men with moderate ED and individuals who did not achieve satisfactory results with the 50 mg dose. It balances potency and tolerability.

3. Avanafil 200 mg

It is the maximum strength for severe ED. Avanafil is suitable for men with more severe ED or those who did not respond adequately to 100 mg. It provides robust results but has a higher risk of side effects. Use only under medical supervision.

Choosing the Right Dose

For Beginners

Start with 50 mg to assess tolerance and effectiveness. If 50 mg is insufficient, your doctor may increase the dose to 100 or 200 mg as needed.

For Sensitive Individuals

Start with 50 mg or consult your doctor about a lower dose.

For Severe ED

A 100 or 200 mg dose may be appropriate. But always consult a healthcare provider.

Avoid Alcohol: Alcohol can reduce the effectiveness of Avanafil and increase the risk of side effects like dizziness or low blood pressure.

Avoid grapefruit and its juice: they can interfere with drug metabolism,

1. Medical Conditions

Heart Problems

Avoid if you have severe cardiovascular conditions such as:

• Unstable angina.
• Recent heart attack or stroke (within the last 6 months).
• Severe heart failure.

Use it cautiously if you have any history of heart disease.

Blood Pressure Issues

Not recommended for individuals with very low blood pressure (hypotension) or uncontrolled high blood pressure. Use it cautiously if you are taking medications to manage blood pressure.

Liver or Kidney Disease

Dose adjustments may be necessary for individuals with moderate-to-severe liver or kidney impairment.

Eye Disorders

Avoid if you have a history of non-arteritic anterior ischemic optic neuropathy (NAION) or other retinal conditions.

Peyronie's Disease

Use it cautiously if you have a penile deformity or scarring, as it may increase the risk of complications.

Blood Disorders

Conditions like sickle cell anemia, leukemia, or multiple myeloma may increase the risk of priapism (prolonged erection).

2. Drug Interactions

Nitrates

Never take Avanafil with nitrate medications (e.g., nitroglycerin) used for chest pain, as this can cause a dangerous drop in blood pressure.

Alpha-Blockers

Use it cautiously if you are taking medications for high blood pressure or prostate problems, as combining these drugs may lead to severe hypotension.

Other PDE5 Inhibitors

Avoid using Avanafil with other ED medications like sildenafil (Viagra) or tadalafil (Cialis).

CYP3A4 Inhibitors

Medications such as ketoconazole, ritonavir, and erythromycin can increase Avanafil levels in the blood, raising the risk of side effects.

Older Individuals

Older men may require lower doses because of slower drug metabolism.

Pregnancy and Breastfeeding

It is not for use by women; avoid it during pregnancy and breastfeeding.

Children and Adolescents

It is not suitable for individuals under 18 years of age.

While common side effects are usually mild and resolve naturally, consult your healthcare provider if symptoms persist for a few hours and do not go away or interfere significantly with daily activities.

By understanding and managing these potential side effects, you can use Avanafil 50 mg safely and effectively for erectile dysfunction. Always follow your doctor’s recommendations.

• Headache
• Flushing
• Nasal Congestion
• Dizziness
• Indigestion (Dyspepsia)
• Nausea
• Back Pain or Muscle Aches
• Vision Changes
• Fatigue
• Diarrhea

• Priapism (Prolonged and painful erection lasting longer than 4 hours)
• Sudden Vision Loss
• Sudden Hearing Loss
• Chest Pain or Irregular Heartbeat
• Severe Allergic Reaction (Anaphylaxis)
• Severe Drop in Blood Pressure
• Severe Skin Reactions
• Difficulty Breathing or Shortness of Breath
• Seizures
• Pulmonary Issues

How does Avanafil 50 mg Stand Out?

Its rapid onset makes it ideal for unplanned sexual activity. It offers a more comfortable experience for men sensitive to other ED treatments. It is perfect for men seeking minimal side effects. Its enhanced selectivity reduces the risk of common PDE5-related side effects.

Why should you use Avanafil 50mg?

Avanafil 50 mg combines speed, effectiveness, and tolerability, making it a standout option among ED medications. It is a perfect ED remedy for men seeking a fast-acting and well-tolerated treatment.

What are the unique features of Avanafil?

Avanafil treats erectile dysfunction (ED) by improving blood flow to the penis, enabling a firm and lasting erection during sexual arousal. Its unique characteristics, such as rapid onset and high selectivity for PDE5, contribute to its effectiveness.

What is the safe and effective way to take Avanafil?

Take as prescribed and avoid overdose. Drink plenty of water to reduce the risk of dehydration-related side effects like headaches. Avoid Alcohol. Excessive alcohol consumption can reduce the effectiveness and increase the risk of side effects like dizziness or low blood pressure. Avoid Grapefruit and Grapefruit Juice, as they can interfere with the metabolism of Avanafil, increasing the risk of side effects. Avoid High-Fat Meals. While Avanafil is less affected by food than sildenafil, high-fat meals may slightly delay its effects.

How do you minimize Side Effects?

Take Avanafil 50 mg exactly as prescribed by your doctor. Avoid alcohol and grapefruit juice because they can increase the likelihood of side effects. Stay hydrated, eat a light meal before taking the medication, and inform your doctor about all pre-existing conditions and current medications.

What are the risk factors for Avanafil?

Avoid the medication if you have pre-existing conditions, such as cardiovascular diseases, including heart attack or stroke, retinal disorders, a history of vision loss, or liver or kidney impairments. Drug Interactions: Taking Avanafil with nitrates, alpha-blockers, or contraindicated medications increases the risk. Overdose: Exceeding the prescribed dose raises the likelihood of severe side effects.

When do you seek emergency help?

Call emergency services or visit a hospital immediately if you experience chest pain or difficulty breathing, a prolonged erection lasting over four hours, vision or hearing loss, or severe allergic reactions such as swelling, rash, or trouble breathing.