Sildenafil Citrate (100 mg) is a potent phosphodiesterase type 5 (PDE5) inhibitor that increases blood flow to the penis, ensuring a firm and sustained erection.
Dapoxetine (60 mg) is a short-acting selective serotonin reuptake inhibitor (SSRI) that delays ejaculation by modulating serotonin activity in the brain.
- Sildenafil Citrate (100 mg)–Mechanism of Action
Type: Phosphodiesterase type 5 (PDE5) inhibitor.
How It Works
Increases cGMP Levels
Sildenafil blocks the PDE5 enzyme, which breaks down cyclic guanosine monophosphate (cGMP). CGMP relaxes smooth muscles and dilates blood vessels in the penis.
Enhances Blood Flow
Relaxed blood vessels allow increased blood flow to the corpora cavernosa, the spongy tissues in the penis.
Erection Support
During sexual stimulation, increased blood flow results in a firm and sustained erection.
Onset: Starts working within 30-60 minutes.
Duration: Effects last for 4-6 hours, ensuring sufficient time for sexual activity.
- Dapoxetine (60 mg)-Mechanism of Action
Type: Selective serotonin reuptake inhibitor (SSRI).
How It Works
Serotonin Modulation
Dapoxetine increases serotonin levels by inhibiting its reuptake into nerve cells. Serotonin regulates mood and emotions and helps control the ejaculatory reflex.
Delays Ejaculation
Higher serotonin activity improves communication in the sacral spinal reflex center, delaying signals that trigger ejaculation. It leads to a longer duration of Intravaginal Ejaculatory Latency Time (IELT).
Improves Ejaculatory Control
It helps men better control ejaculation, reducing anxiety and enhancing confidence.
Onset: Takes effect within 1-3 hours.
Duration: Provides ejaculatory control for 4-6 hours.
How They Work Together
Erection Support
Sildenafil ensures a firm and lasting erection during sexual stimulation.
Delayed Ejaculation
Dapoxetine provides better control over ejaculation, prolonging the duration of intercourse.
Enhanced Sexual Performance
The combination treats both the physical (ED) and psychological (PE) aspects of sexual performance, improving satisfaction for both partners.