Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that increases blood flow to the penis during sexual arousal. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that delays ejaculation by modulating serotonin levels.
Mechanism of Action
Sexual arousal is necessary for the medication to work because it triggers the release of nitric oxide (NO) in the penile tissue. Nitric oxide activates Guanylate Cyclase enzymes and increases cyclic guanosine monophosphate (cGMP) levels in the penile tissues.
CGMP relaxes the smooth muscles of the blood vessels in the penis, allowing them to dilate and fill with blood, resulting in an erection.
How do PDE5 enzymes hinder erection?
The enzyme PDE5 breaks down cGMP, reducing blood flow and causing the erection to subside.
How does Sildenafil help?
Sildenafil increases blood flow to the penis, enabling an erection during sexual stimulation. Sildenafil inhibits PDE5, preventing the breakdown of cGMP. It allows cGMP levels to remain elevated, ensuring prolonged relaxation of blood vessels and sustained blood flow to the penis during sexual arousal. During sexual stimulation, Sildenafil ensures a firm erection by maintaining high cGMP levels. Sildenafil works within 30–60 minutes of ingestion. It remains effective for 4–6 hours, enabling consistent erectile function during this window.
How does Dapoxetine work for Premature Ejaculation (PE)?
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that delays ejaculation by modulating serotonin levels in the brain.
Mechanism of Action
Our central nervous system (CNS) and brain serotonin levels control ejaculation. Lower serotonin activity in brain pathways can lead to premature ejaculation. Dapoxetine modulates serotonin levels, delaying the ejaculatory response. Dapoxetine provides greater control over ejaculation, extending the duration of sexual activity.
Role of Dapoxetine
Dapoxetine increases serotonin levels in the synaptic cleft, enhancing communication between nerve cells. It strengthens the signals in the spinal ejaculatory reflex pathway, delaying the ejaculatory response. Our body absorbs Dapoxetine rapidly, taking effect within 1–2 hours after ingestion. It remains effective for the duration of sexual activity, providing greater control over ejaculation.
Combined Mechanism of Extra Super P Force
Sildenafil + Dapoxetine work synergistically to address both ED and PE simultaneously. Sildenafil increases blood flow to the penis, enabling a firm and lasting erection during sexual arousal. Dapoxetine delays ejaculation, allowing for prolonged sexual activity and enhanced satisfaction.
Dual Benefit
It addresses both the inability to maintain an erection (ED) and the inability to control ejaculation (PE) in a single tablet. Improves sexual performance and confidence by ensuring better control and reliability.