Extra Super Tadarise 100 mg combines Tadalafil 40 mg and Dapoxetine 60 mg to address erectile dysfunction (ED) and premature ejaculation (PE) simultaneously.
How Tadalafil Works (Treats ED)?
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor that improves blood flow to the penis, enabling potent and longer-lasting erections during sexual stimulation.
Mechanism of Action
Enhancing cGMP Levels
During sexual arousal, our body releases nitric oxide (NO) in the penile tissues. NO activates Guanylate Cyclase enzymes, which increases cyclic guanosine monophosphate (cGMP) levels in the erectile tissues, namely the corpus cavernosum. CGMP relaxes the smooth muscles in the walls of blood vessels, allowing them to dilate and increase blood flow to the penis.
Role of PDE5 Enzyme
PDE5 is an enzyme that breaks down cGMP, which reduces blood flow and causes the erection to subside.
Tadalafil Role
Tadalafil inhibits the action of PDE5, ensuring sustained levels of cGMP. It maintains the relaxation of blood vessels and promotes continuous blood flow to the penis during sexual arousal, which results in a firm and lasting erection during sexual activity.
How Dapoxetine Works (Treats PE)
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that helps delay ejaculation by influencing serotonin levels in the brain.
Mechanism of Action
The spinal ejaculatory reflex regulates ejaculation urges, and serotonin activity in the central nervous system influences the ejaculation reflexes. Low serotonin levels or activity in specific brain pathways can lead to premature ejaculation.
Dapoxetine Role
Dapoxetine increases serotonin levels in the synaptic cleft, improving communication between nerve cells. It strengthens the signals in the spinal ejaculatory reflex pathway, delaying ejaculation. It results in improved control over ejaculation and prolonged sexual activity.
Combined Effect of Tadalafil + Dapoxetine
Extra Super Tadarise provides a dual-action solution for ED and PE
Tadalafil’s Action (ED)
Enhances blood flow to the penis, ensuring firm and long-lasting erections during sexual stimulation.
Dapoxetine Action (PE)
Increases serotonin activity, delaying ejaculation for extended and more satisfying sexual activity.
Steps after Taking Extra Super Tadarise
Within 30–60 Minutes, Tadalafil works by increasing cGMP levels, relaxing blood vessels, and improving blood flow to the penis.
Within 1–2 hours, Dapoxetine affects serotonin levels, delaying the ejaculatory reflex and allowing greater control during intimacy.
During Sexual Activity
Tadalafil ensures a strong and sustained erection during sexual arousal. Dapoxetine delays ejaculation, allowing for prolonged and satisfying intercourse.
After Sexual Activity
The effects of Dapoxetine wear off after sexual activity. Tadalafil remains active in the body for up to 36 hours, enabling additional opportunities for intimacy with no re-dosing.