Filagra 100mg-Budget Friendly Erectile Dysfunction Med

Sildenafil specifically targets PDE5, predominantly found in penile tissue, minimizing effects on other PDE enzymes in the body. Filagra 100mg works only when sexually stimulated. Sexual arousal triggers the release of nitric oxide (NO) in the erectile tissue of the penis. NO boosts cGMP production, enhancing blood flow and causing an erection.

Initial Phase: Sexual Stimulation and Nitric Oxide Release

Sexual arousal triggers the release of nitric oxide (NO) from the nerve endings and endothelial cells in the penile tissue. Nitric oxide acts as a signaling molecule to kick off a cascade of reactions that prepare the blood vessels to increase blood flow.

Activation of cGMP

Nitric oxide stimulates the enzyme Guanylate Cyclase, which converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). CGMP is the primary mediator responsible for relaxing the smooth muscle cells in the corpus cavernosum, the spongy erectile tissue of the penis.

Smooth Muscle Relaxation and Vasodilation

Elevated cGMP levels lead to smooth muscle relaxation in the walls of the blood vessels within the penis. This relaxation causes the dilation of blood vessels, allowing a larger volume of blood to flow into the corpus cavernosum. The inflow of blood results in the penis becoming engorged, leading to an erection.

Role of PDE5 Enzyme and Sildenafil’s Action

Under normal conditions, the enzyme phosphodiesterase type 5 (PDE5) breaks down cGMP, hindering the erection process. Sildenafil Citrate in Filagra 100mg inhibits the action of PDE5, preventing the degradation of cGMP. By maintaining higher levels of cGMP, Sildenafil prolongs the relaxation of smooth muscles and sustains the blood flow necessary for an erection.

Sustained Erection and Detumescence

As long as sexual stimulation continues, the nitric oxide pathway keeps producing cGMP, which is protected from degradation by Sildenafil. Once stimulation ends or after ejaculation, cGMP levels naturally decrease, and the penis returns to its flaccid state (detumescence).

Pharmacokinetics

• Absorption: After oral administration, the body absorbs Sildenafil rapidly into the bloodstream, with maximum plasma concentrations reached within 30-120 minutes.
• Metabolism: The enzyme CYP3A4 in the liver metabolizes the medication.
• Excretion: The body excretes the metabolites through feces and, to a lesser extent, urine

Standard Dosage Options

Filagra 25mg: Prescribed to individuals who may need a lower dose because of sensitivity to the drug or for beginners. Suitable for patients with certain medical conditions requiring milder action.

Filagra 50mg: It is the usual starting dose for most men with moderate erectile dysfunction (ED). Commonly, the dose is effective for achieving satisfactory results. 

Filagra 100mg: It is a higher dose for individuals with more severe ED or when the 50mg dose is insufficient. Doctors do not recommend it for first-time users unless prescribed by a doctor.

Dosage Guidelines

Swallow the tablet with water. Do not crush, chew, dissolve, split, or break the pill in the mouth or outside. Take the Filagra dose 30-60 minutes before sexual activity. Do not exceed one dose in 24 hours to avoid overdose side effects. You can take it with or without meals, though a high-fat meal may delay its effectiveness.

Higher dose (100mg): Doctors prescribe it when lower doses (25mg or 50mg) do not produce the desired effect. It calls for careful monitoring of potential side effects.

Lower dose (25mg): Doctors recommend it for older adults, those with kidney or liver impairments, or individuals taking medications that interact with Sildenafil.

Older Patients: Start with the lowest effective dose (e.g., 25mg).

Patients with Medical Conditions: Lower Filagra dosages help those with cardiovascular, hypertension, or kidney/liver problems.

Patients on Other Medications: Doctors may suggest lower doses when using drugs like nitrates or alpha-blockers because of potential interactions.

Always consult a doctor before taking Filagra, especially if you have pre-existing medical conditions or are taking other medications. Disclose your complete medical history, including any heart, liver, kidney, or blood pressure issues.

Avoid Certain Medications

Do not take Filagra with nitrates (commonly prescribed for chest pain), as this can cause a dangerous drop in blood pressure. Avoid using it with alpha-blockers, antifungal drugs, or HIV protease inhibitors without medical guidance.

Limit Alcohol Consumption

Alcohol can reduce the effectiveness of Filagra and increase the risk of side effects like dizziness or low blood pressure.

Avoid Grapefruit Products

Grapefruit and grapefruit juice can interfere with the metabolism of Sildenafil, increasing the risk of side effects.

Monitor for Side Effects

Common side effects include headache, flushing, dizziness, nasal congestion, and upset stomach. Serious side effects, like vision or hearing loss, chest pain, or a prolonged erection lasting over four hours (priapism), require immediate medical attention.

Use with Caution in Specific Conditions

• Heart Problems: Avoid Filagra if you have severe cardiovascular issues or if your doctor suggests against sexual activity for health reasons.
• Low Blood Pressure (Hypotension): Use cautiously, as Filagra can lower blood pressure further.
• Liver or Kidney Disease: You may need dose adjustments.

Pregnancy and Breastfeeding

Filagra is not for use by women. Pregnant or breastfeeding women should avoid this medication.

Driving and Operating Machinery

Avoid activities requiring alertness (e.g., driving) if you experience dizziness, vision changes, or drowsiness after taking Filagra.

Storage and Handling

Store Filagra at room temperature, away from moisture and heat. Keep out of reach of children.

• Headache
• Flushing (Warmth or Redness)
• Redness or warmth in the face, neck, or chest
• Dizziness or Lightheadedness
• Nasal Congestion
• Runny Nose
• Upset Stomach
• Indigestion (Dyspepsia)
• Vision Changes
• Blurred vision or a blue-tinted vision
• Back or muscle pain
• Nausea
• Sensitivity to Light (Photophobia)

Prolonged or Painful Erection (Priapism)

An erection lasting over four hours is a condition that can cause permanent damage to the penis if not treated promptly.

Sudden Vision Loss

Loss of vision in one or both eyes because of non-arteritic anterior ischemic optic neuropathy (NAION) is a rare but serious side effect.

Hearing Problems

Sudden decrease or loss of hearing, ear ringing (tinnitus), or dizziness.

Severe Allergic Reactions (Anaphylaxis)

Symptoms include:

• Swelling of the face, lips, tongue, or throat.
• Difficulty breathing.
• Severe skin rash or itching.

Cardiovascular Problems

Symptoms include:

• Severe chest pain or tightness.
• Irregular heartbeat or palpitations.
• Shortness of breath or fainting.
• Risky for individuals with pre-existing heart conditions.

Low Blood Pressure (Hypotension)

A significant drop in blood pressure may occur, particularly if taken with nitrates or alpha-blockers.

Symptoms include

• Dizziness
• Fainting
• Severe fatigue

Stroke or Heart Attack

It can happen to individuals with a history of cardiovascular disease.

• Symptoms include
• Sudden weakness
• Slurred speech
• Numbness on one side of the body
• Chest pain

Severe Skin Reactions

Rare conditions like Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) involve severe skin peeling, blisters, and fever.

Seizures

Uncontrolled convulsions or fits in rare cases. Stop taking Filagra immediately. Seek emergency medical attention.

How long does the action of Filagra 100mg last?

The effects last for about 4-6 hours, during which sexual stimulation will help you attain an erection.

How do you minimize side effects?

Take Filagra with water on an empty stomach or after a light meal. Avoid alcohol and grapefruit juice while using the medication. Start with the prescribed dose and do not exceed the recommended amount.

When to Seek Medical Help?

While the above side effects are common and usually not serious, seek immediate medical attention if you experience

• A severe chest pain or irregular heartbeat (arrhythmia).
• Prolonged erection lasting over four hours (priapism).
• A sudden decrease or loss of vision or hearing.
• Severe dizziness or fainting.

When do you avoid Filagra 100mg?

Do not use Filagra if you have a history of heart problems, severe vision issues, or allergies to Sildenafil.