Sildenafil Citrate (100 mg) is a potent PDE5 inhibitor that increases blood flow to the penis, treating erectile dysfunction effectively. Dapoxetine (60 mg) is a short-acting SSRI that delays ejaculation by enhancing serotonin activity in the central nervous system.
- Sildenafil Citrate (100 mg)
Mechanism of Action
Type: Phosphodiesterase type 5 (PDE5) inhibitor.
How It Works
Increases cGMP Levels
Sildenafil blocks the PDE5 enzyme, which breaks down cyclic guanosine monophosphate (cGMP), a molecule that promotes blood vessel relaxation.
Enhances Blood Flow
Elevated cGMP levels cause the smooth muscles in the walls of blood vessels in the penis to relax. This relaxation improves blood flow to the corpora cavernosa, the spongy tissues of the penis responsible for erections.
Erection Support
During sexual stimulation, this increased blood flow leads to a firm and sustained erection.
Onset: Begins working within 30-60 minutes after ingestion.
Duration: Effects last for up to 4-6 hours, ensuring sufficient time for planned sexual activity.
- Dapoxetine (60 mg)
Mechanism of Action
Type: Selective Serotonin Reuptake Inhibitor (SSRI).
How It Works
Modulates Serotonin Activity
Dapoxetine increases serotonin levels by inhibiting its reuptake into nerve cells.
Serotonin is a neurotransmitter involved in mood and emotion regulation, arousal, and the ejaculatory reflex.
Delays Ejaculation
Higher serotonin activity improves communication in the sacral spinal reflex center, delaying the signals that trigger ejaculation. This results in prolonged Intravaginal Ejaculatory Latency Time (IELT), allowing men to last longer during intercourse.
Improves Ejaculatory Control
It enhances a man’s ability to control ejaculation, reducing anxiety and improving confidence.
Onset: Takes effect within 1-3 hours after ingestion.
Duration: Provides control over ejaculation for up to 4-6 hours.