Generic Fosamax Eradicates Osteoporosis Problems

Alendronate present in Generic Fosamax demonstrates favored localization to sites of bone resorption, precisely under osteoclasts. The osteoclasts stick normally to the bone surface but are deprived of the tangled border suggestive of active resorption. Alendronate does not hinder osteoclast recruitment or attachment, but inhibits osteoclast activity. Though merged in bone matrix, alendronate is not pharmacologically active and hence must be continuously taken to suppress osteoclasts on newly formed resorption surfaces. Alendronate treatment decreases bone turnover (i.e., the number of sites at which bone is remodeled). Hence, bone formation outdoes bone resorption at these remodeling sites, leading to advanced gain in bone mass.

Generic Fosamax is taken as

• 10 mg OD or 70 mg (tablet or oral solution) once in a week in case of osteoporosis in postmenopausal women and in men
• 5 mg OD or 35 mg once weekly for preventing osteoporosis in postmenopausal women
• 5 mg or 10 mg* OD in case of glucocorticoid-induced osteoporosis
• 40 mg OD for six months in case of Paget's disease of the bone

Swallow tablets with 6-8 ounces plain water at least 30 minutes prior to first food, drink, or medication of the day.

Oral solution to be swallowed with at least two ounces of water.

*For postmenopausal women not on estrogen therapy.OD: Once a day

• Upper Gastrointestinal Adverse Reactions can occur and this medication needs to be discontinued if new or worsening symptoms occur.
• Hypocalcemia can exacerbate and must be corrected before use.
• Severe Bone, Joint, Muscle Pain may occur.
• Osteonecrosis of the Jaw has been reported.
• Atypical Femur Fractures have been reported.
• Patients with new thigh or groin pain should be evaluated to rule out an incomplete femoral fracture.

Most common adverse reactions (greater than or equal to 3%) are abdominal pain, acid regurgitation, constipation, diarrhea, dyspepsia, musculoskeletal pain, nausea.

Stop the usage of Generic Fosamax if any of these side-effects occur:

• Chest pain and heartburn
• Difficulty or pain on swallowing
• Pain or burning in the ribs or back
• Severe heartburn, burning pain in upper stomach, or bloody cough
• Unusual or sudden pain in your thigh or hip, jaw pain, numbness, or swelling
• Severe joint, bone, or muscle pain

Which drugs cannot be taken with Generic Fosamax?

Calcium supplements, antacids, or oral medications containing multivalent cations interfere with absorption of alendronate and hence should not be taken with Generic Fosamax simultaneously

Aspirin/nonsteroidal anti-inflammatory drugs that may worsen gastrointestinal irritation and hence, should be prescribed with Generic Fosamax with caution.

What should be done in case of Overdose?

• No specific info is available on the treatment of overdosage with Generic Fosamax. Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events can occur.
• Milk or antacids should be given to impasse alendronate.
• Vomiting should not be induced and the patient should remain fully upright as esophageal irritation can occur.
• Dialysis would not be beneficial in case of Overdose of Generic Fosamax

What if a dose of Generic Fosamax is missed?

Take the missed dose of Generic Fosamax as soon as you recall. If the dose is missed and the time is near to the next scheduled dose, skip the missed dose and take the next scheduled dose on time. Do not duplicate the dose in order to make up for the missed dose.