Kamagra polo contains sildenafil citrate as the active ingredient. After rapid absorption, Sildenafil citrate in Kamagra Polo acts in the body to block the actions of the enzyme phosphodiesterase 5 enzyme which is solely responsible for ED. Inhibition of the actions of PDE-5 causes the biochemicals nitric oxide and guanylyl cyclase to increase in the body. Elevation in the NO mediated increase in the concentration of the enzymeguanylyl cyclase, in turn increases the biosynthesis of a nucleotide called cyclic guanosine monophosphate (cGMP). This cGMP is a powerful and an effective natural vasodilator present in the body as well as in the penile regions. Levels of cGMP increases after administration of Kamagra Polo widens the blood vessels that supply the blood to the penis. It is also responsible for the relaxation of the penile smooth muscles. Due to this more blood fills the penis and is retaining for longer time so that a firm and long lasting penile erection is achieved in order to indulge in a satisfactory sexual intercourse.