Sildenafil citrate present in Ladygra is a selective inhibitor of cGMP-specific PDE5 and is effective in the treatment of erectile dysfunction in males. In addition to playing physiological roles in males’ sexual responses, this medicine can also be effective in females’ sexual arousal. Sildenafil’s main mechanism of action is enhancing the effect of nitric oxide by the inhibition of cGMP enzymatic destruction. The specific-PDE5 inhibitor leads to the deactivation of cGMP in both the clitoris (in females) and the penis. In addition to the vagina, PDE5 is also present in the clitoris and the smooth muscles of the labia. Consumption of sildenafil results in hyperpolarization and relaxation of the tissue which eventually leads to increase in blood flow, hyperemia, and inflation. Thus, highly effective in females’ sexual function, specifically in sexual arousal. Its effects on increasing sexual arousal and lubrication, and loosening of the smooth muscles, mainly in arteries, veins, and arterioles of the vagina and the clitoris leads to resolution of FSD in females.