Generic Ibuprofen 100mg - Treatment for Inflammation and Pain

Generic Ibuprofen inhibits the cyclooxygenase (COX) enzymes that are responsible for conversion of arachidonic acid to prostaglandins. Thus, by inhibiting the COX enzymes, ibuprofen inhibits the prostaglandin biosynthesis which are key mediators of inflammation. Inhibition of prostaglandin synthesis in turn, leads to inhibition of bradykinin actions which inhibits the sensation of perception of pain. Like aspirin, ibuprofen is a nonselective COX inhibitor and blocks two forms of cyclooxygenaseviz.COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity occurs due to the inhibition of COX-2, which decreases the synthesis of prostaglandins which control inflammation, pain, fever, and swelling. Antipyretic effects may be due to action a part of brain which increases peripheral blood flow, widening of the blood vessels in the body, and consequent temperature reduction in the body.

Dysmenorrhea

200 to 400 mg orally every 4 to 6 hours as needed

Osteoarthritis and Rheumatoid arthritis

1200 to 3200 mg orally per day in divided doses

Pain

200 to 400 mg orally every 4 to 6 hours as needed

The usual dose for adults is one or two 200mg tablets 3 times a day. If this doesn’t work, doctor may prescribe a higher dose of up to 600mg to take 4 times a day.

• Generic Ibuprofen tablets are to be taken with food or a drink of milk to reduce the chance of an upset stomach. Consumption on an empty stomach is not recommended.
• Take the lowest dose for the shortest time. Don't use it for a long time unless recommended by a doctor.
• Ibuprofen Generic should not be consumed orally if you:
  • Are allergic to ibuprofen
  • Have a history of asthma, a raised, itchy red rash (urticaria), swelling underneath your skin (angioedema) or swelling of the inside of your nose (rhinitis)
  • are taking aspirin or any other NSAIDs
  • Have asthma or another allergic illness
  • Are planning pregnancy or are already pregnant
  • Are breastfeeding

• Upset stomach
• Mild heartburn
• Nausea
• Vomiting
• Bloating and gas
• Diarrhea
• Constipation
• Dizziness
• Headache
• Nervousness
• Mild itching or rash or tinnitus.

If there are signs of an allergic reactions like sneezing, runny or stuffy nose, wheezing, hives, swelling of your face, lips, tongue, or throat, seek the doctor’s help instantly.

Discontinue Generic Ibuprofen and call the doctor promptly if there are:

• Changes in vision
• Heaviness of breath (even with mild exertion)
• Swelling or rapid weight gain
• Skin rash
• Signs of stomach bleeding like bloody stools, coughing up blood or coffee colored vomit

Which drugs cannot be taken with the drug?

Generic Ibuprofen should not be taken with medicines like-

• Blood-thinning medicines (e.g. Warfarin)
• Anti-inflammatory painkillers (e.g. Aspirin, diclofenac, mefenamic acid and naproxen)
• Anti-hypertensives
• Steroid medicines such as betamethasone, dexamethasone, hydrocortisone or prednisolone
• Antibiotics like ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin
• Antidepressants
• Antidiabetics

What should be done in case of Overdose

In cases of overdose, the stomach should be emptied by vomiting or lavage, though little drug will likely be recovered if more than an hour has elapsed since ingestion. Because the drug is acidic and is excreted in the urine, it is theoretically beneficial to give alkali and persuade diuresis. In addition to supportive measures, oral activated charcoal may help to decrease the absorption and reabsorption of generic ibuprofen tablets.

What if a dose is missed

• Since, Generic Ibuprofen medicine is taken as needed, dosing schedule may not be required.
• If on a schedule, missed dose should be consumed as soon as remembered.
• Skip the missed dose if it is almost time for your next scheduled dose.
• Using extra medicine to make up the missed dose should be avoided.