Generic Ibuprofen inhibits the cyclooxygenase (COX) enzymes that are responsible for conversion of arachidonic acid to prostaglandins. Thus, by inhibiting the COX enzymes, ibuprofen inhibits the prostaglandin biosynthesis which are key mediators of inflammation. Inhibition of prostaglandin synthesis in turn, leads to inhibition of bradykinin actions which inhibits the sensation of perception of pain. Like aspirin, ibuprofen is a nonselective COX inhibitor and blocks two forms of cyclooxygenaseviz.COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity occurs due to the inhibition of COX-2, which decreases the synthesis of prostaglandins which control inflammation, pain, fever, and swelling. Antipyretic effects may be due to action a part of brain which increases peripheral blood flow, widening of the blood vessels in the body, and consequent temperature reduction in the body.