You need sexual arousal whenever you want the medication to take effect and get an erection. Sildenafil and tadalafil are phosphodiesterase type five (PDE 5) inhibitors. Both work by increasing blood flow in the male genital organ and trigger a sturdy and sustainable erection for a long duration.
Sildenafil and tadalafil inhibit (block or slow down) the enzyme PDE5, which regulates blood flow in the penis. By blocking this enzyme, sildenafil increases cyclic guanosine monophosphate (cGMP) levels. CGMP relaxes the smooth muscle cells in the blood vessels of the penis, allowing for increased blood flow during sexual arousal.
Like sildenafil, tadalafil also inhibits PDE5, promoting blood vessel relaxation and increasing blood flow to the penis. However, tadalafil has a longer half-life, which extends the period of effectiveness, allowing for more prolonged spontaneity.
The effects of sildenafil kick in within 30-60 minutes but last for about 4-6 hours, providing a reliable timeframe for sexual activity. Tadalafil takes longer to kick in at peak levels of about 1-2 hours. It lasts much longer-up to 36 hours.
Overall Impact of Sildenafil + Tadalafil
During sexual arousal, Sildalis enhances blood flow to the penile tissue, enabling a firm erection by relaxing blood vessels and increasing blood flow to the area. However, it only works when there is sexual stimulation, as the initial release of nitric oxide (NO) during arousal is necessary to trigger the production of cGMP, which the medication then amplifies.